Web3 feb 2011 · Effective hemostasis relies on the timely formation of α-thrombin via prothrombinase, a Ca(2+)-dependent complex of factors Va and Xa assembled on the … Web15 gen 2000 · The Arg320-Ile321 bond is 1 of 2 sites in prothrombin cleaved by Factor Xa in the prothrombinase complex to form thrombin. Substitution of His for Arg at this site …
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Web28 dic 2024 · This variant is also known as c.958C>T (p.Arg320*) in the literature. ClinVar contains an entry for this variant (Variation ID: 185048). This variant is expected to delete amino acid residues Arg300-Thr328 of the RAD51D protein, thereby removing the C-terminus of the ATPase domain (PMID: 14704354, 19327148, 21111057). Web15 nov 2012 · Regione colore grigio la presenza di un fenile su C-10 riduce affinità di legame ed attività antineoplastica La presenza di un fenile su C-3΄ riduce interazione con Arg320; Asp26; Val23; Ser236 Lo stesso effetto in questa regioni può essere ottenuto inserendo un t-butile o un acetato sulC-4 del PTX Poliedro colore giallo rappresenta una … hengtian wealth investment management co. ltd
Amide H/2H Exchange Reveals a Mechanism of Thrombin …
Web1 mag 2004 · Due to its high substrate specificity, ecarin efficiently converts prethrombin-2, which comprises residues 272–579 of prothrombin, into α-thrombin solely through Arg320-Ile321 cleavage (26, 27). Therefore, we established a line of transformant cells secreting recombinant ecarin for the activation of recombinant human prethrombin-2. Web1 feb 2000 · The Arg320-Ile321 bond is one of two prothrombinase-mediated cleavage sites that generate thrombin. Replacement of Arg with His at this site prevents cleavage by factor Xa, forming a dysfunctional ... Web20 mag 2014 · This strain (Arg320) was detected by the EIA developed against recombinant Mexico virus (rMxV) capsids, but the viral RNA polymerase sequence was closer to Lordsdale virus, in a separate genetic cluster of Norwalk-like viruses. A 3.3 kb cDNA from the RNA polymerase region to the 3′ end of the genome of Arg320 was cloned and … la redoute sneakers homme