Cisplatin and hydration

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August undefined, 2024

WebJan 7, 2024 · Cisplatin has a well-documented array of toxic side-effects, of which some are potentially irreversible, including nephrotoxicity. 1, 2 Accordingly, cisplatin infusion is usually combined with saline to hydrate and mannitol infusion to promote osmotic diuresis to prevent permanent damage to the renal tubules. 2 – 4 WebAbstract. Introduction: Gemcitabine and cisplatin is the standard first-line systemic treatment in patients with advanced cholangiocarcinoma (CCA). However, a substantial number of patients do not qualify for cisplatin due to comorbidities or poor performance status. The phase II pilot study NACHO evaluated the efficacy of nab-paclitaxel (125 …

Frontiers Protective Effect of Mannitol on Cisplatin-Induced ...

WebHyponatremia of grade 3 or above developed in 30.7% of the generic CDDP group compared to 15.1% of the brand-name CDDP group ( P =0.011). Multivariate analysis showed that the use of generic CDDP increased the incidence of hyponatremia (odds ratio =5.661, 95% confidence interval =1.403–22.839; P =0.015). Conclusion: Oncologists … WebJun 23, 2024 · Depending on the protocol, 1 - 2 litres pre-hydration. The patient must have urinated a litre minimum before we proceed. Our cisplat goes in 250 mls usually giving us a final volume of 340 mls. We used to pass Mannitol concurrently but that's now been … grand lucky group

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WebApr 27, 2024 · Currently, the ABC02 regime includes a long hydration schedule based on previous use of high doses of cisplatin and perhaps historically the lack of efficacious antiemetics. Cisplatin is often associated with severe nausea and … WebJun 27, 2024 · 摘要Aims: To ascertain the efficacy and toxicity of cisplatin in combination with adriamycin for patients with metastatic and/or locoregional recurrent nasopharyngeal carcinoma. Patients and Methods: A phase II trial combining cisplatin and adriamycin was conducted in 15 patients with metastatic nasopharyngeal carcinoma. WebDec 12, 2024 · You will need to make sure you are not dehydrated before, during, and after doses of this drug. Drink lots of noncaffeine liquids and have your blood work checked as you have been told by your doctor. This drug may cause nerve problems. These nerve problems can get worse the more times you get this drug. chinese food kannapolis nc

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WebPre-hydration in cisplatin-based CCRT: Effects on tumour concentrations and treatment outcome Pre-hydration reduces cisplatin tumour concentrations in mice, but it does not compromise treatment outcomes in NSCLC patients treated with daily cisplatin and radiotherapy. WebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various side effects which limit its use. Cisplatin mouse models are widely used in studies investigating cisplatin therapeutic and toxic effects. grandlucky onlineWebApr 12, 2024 · AKI, present in 20–30% of patients’ cisplatin exposed, is usually non-oliguric. Moreover, urinalysis may detect glycosuria and a low-grade proteinuria. AKI-related cisplatin may also be associated with tubulopathies, such as Fanconi-like syndrome, hypomagnesemia, salt-loosing syndrome and distal renal tubular acidosis . Tubular … grand lucayan resort bahamas rooms

"WebNational Center for Biotechnology Information " - Cisplatin and hydration

Cisplatin and hydration

The Effect of Intravenous Mannitol Combined With Normal Saline …

WebCisplatin(cis-dichlorodiammineplatinum)–platinum coordination complex is an effective chemotherapy against a wide spectrum of tumors such as testicular, head and neck, ovarian, lung, cervical, and bladder cancers. Nephrotoxicity is the dose-limiting toxicity of cisplatin. Cisplatin induces the production of ROS WebSep 1, 2024 · Cisplatin Dosage and Administration Hydration and Anti-Emetic Treatment Patients treated with Cisplatin for injection must receive appropriate pre-treatment …

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WebRenal protection measures currently being applied include 1) extensive hydration in chemotherapy patients required to clear cisplatin from the kidneys and 2) the use of other platinum derivatives with fewer side effects such as carboplatin and oxaliplatin, but the therapeutic range of such drugs is also relatively narrow (Kruger et al., 2015). WebApr 12, 2024 · All doses of cisplatin were diluted in 500 ml of 0.9% saline and infused over 2–3 h. Patients in the mannitol cohort received 20 g admixed in the 0.9% 100 ml saline prehydration. All patients received antiemetic premedication such as dexamethasone, a H 2 receptor blocker and diphenhydramine. Assessment of outcome

WebIn conventional treatment regimens employing doses of cisplatin of less than 100 mg/m (2) in patients with normal renal function, pre- and post-hydration (3 l/m (2) at least 12 h pre-cisplatin and 24 h post-cisplatin) alone should be routinely used. WebApr 12, 2024 · Cisplatin is a platinum-based chemotherapy agent that currently used as front-line therapy in the treatment of various solid organ cancers, including head and neck, lung, testis, ovary, breast, bladder cancer and sarcoma [1–7]. The therapeutic effects of cisplatin are significantly improved by dose escalation.

WebNational Center for Biotechnology Information WebJul 15, 2015 · Hydration is recommended to induce diuresis and reduce the concentration of cisplatin in the kidneys. Isotonic saline (0.9% sodium chloride) is recommended for hydration fluids, and many...

WebFor cisplatin, hydration is always indicated and mannitol may be useful in selected settings. Furosemide is probably not generally useful. For carboplatin, hydration is …

WebCisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, … grand lucayan beach \u0026 golf resort reviewsWebSep 4, 2013 · Cisplatin was administered with pre- and post-hydration containing 10 mEq of potassium chloride in 500 ml of fluid over a 60-min period. Immediately before the administration of cisplatin, mannitol (20%, 200 ml) was administered as forced diuresis over 30 min. And magnesium sulfate (8 mEq) was added to pre-hydration. Results chinese food katy chinese food kawanahttp://school.freekaoyan.com/hongkong/cuhk/2024/06-27/1498578834645114.shtml chinese food kaysville utahWebPretreatment hydration: Patients should be adequately hydrated before and for 24 hours after administration of cisplatin to ensure good urinary output and minimise nephrotoxicity. Hydration may be achieved by IV infusion of 2 litres of either sodium chloride IV infusion 0.9% or glucose-saline (e.g. glucose 4% in one-fifth sodium grand lucky mall of indonesiaWebFeb 16, 2016 · In this study, we assessed nephrotoxicity in daily practice among patients treated with high-dose cisplatin (100 mg/m 2 on days 1, 22, and 43), concurrently with chemoradiotherapy (CCRT) and the impact on treatment modifications. Methods: 208 patients with advanced-stage malignancies of the head and neck region were evaluated. grand lucayan resort bahamas vacationWebOct 19, 2024 · This information will help you hydrate yourself to get ready for your cisplatin chemotherapy. Cisplatin can affect your kidneys. To keep your kidneys from getting damaged, you’ll need to drink plenty of liquids before you get cisplatin chemotherapy. chinese food kanata centrum