Web1 de jan. de 2012 · However, while trying to provide a mathematical explanation, researchers have discovered that under certain conditions the opposite situation occurs, i.e., a deeper search results in worse ... WebDescription. The Highest Single Agent (HSA) model, or Gaddum's non-interaction reference (Berenbaum 1989), is based on the intuition that if a combination's effect exceeds those of its constituents, there must be some interaction.
Applying synergy metrics to combination screening data: …
Web1 de set. de 2015 · We note that, max(y 1, y 2) is also the expected response from a popular reference model, called highest single agent (HSA) model (Berenbaum, 1989). If the combination response y c is lower than max(y 1, y 2), then one would intuitively infer antagonism. Therefore, we may use max(y 1, y 2), to distinguish antagonism from non … http://www.mbswonline.com/upload/presentation_6-2-2010-9-54-1.pdf green birthday candles
Synergy scores: HSA and Bliss positive, but Loewe is
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